Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lee, F.T.; Adams, J.B.; Garton, A.J.; Yeaman, S.J.
    Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones (1988), Biochim. Biophys. Acta, 963, 258-264.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.79 Hg2+ 0.005 mM, approx. 50% inhibition, 0.02 mM, approx. 70% inhibition Bos taurus
3.1.1.79 phenylmethanesulfonyl fluoride 0.01 mM, approx. 75% inhibition, 0.01 mM, approx. 90% inhibition Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.79 84000
-
 x * 84000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.79 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.79 phosphoprotein
-
 Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.79 pH 5.0, DE-52, hydroxyapatite Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.79 placenta cotyledon Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.79 0.3
-
 hydrolysis of estradiol-17-beta-oleate Bos taurus
3.1.1.79 2.6
-
 hydrolysis of 1-oleoyl-2-oleylglycerol Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O
-
 Bos taurus 2-oleylglycerol + oleate
-
 ?
3.1.1.79 cholesteryl oleate + H2O 18.5% of activity with 1-oleoyl-2-oleylglycerol Bos taurus cholesterol + oleate
-
 ?
3.1.1.79 dehydroepiandrosterone oleate + H2O 12.9% of activity with 1-oleoyl-2-oleylglycerol Bos taurus dehydroepiandrosterone + oleate
-
 ?
3.1.1.79 estradiol-17-beta-oleate + H2O 17.9% of activity with 1-oleoyl-2-oleylglycerol Bos taurus 17-beta-estradiol + oleate
-
 ?
3.1.1.79 estradiol-17-beta-palmitate + H2O 18.3% of activity with 1-oleoyl-2-oleylglycerol Bos taurus 17-beta-estradiol + palmitate
-
 ?
3.1.1.79 testosterone oleate + H2O 1.4% of activity with 1-oleoyl-2-oleylglycerol Bos taurus testosterone + oleate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.79 ? x * 84000, SDS-PAGE Bos taurus